I've been a vet tech for 14 yrs and this product is great.
My great dane puppy has pancreatic insuffiency. Since she's a growing dane puppy and her food has been increased, we have found that it works better now to crush the pill and feed with a small amount of food before she gets the rest of her food.
She gets Bio Zyme with each meal and by the 2nd day, she had normal stool. She's been on it for 3 weeks now and has gained 15 lbs already. She's still thin but usually dogs with this problem never fully gain the right amount of weight. She was a walking skeleton before and looks so much better now. She's happy too.
I bought this for my 65# pit bull b/c it indicates that using it between meals with a snack may help with overexertion and muscle repair, etc. It says to give 1 pill daily for a 50# dog, but I did that for 3 days and my dog got diarrhea. It subsided right away, and then I administered just 1/2 pill each day and he seems to tolerate it, but not sure if the 1/2 dose will be enough to help him.