Thorne Research Hepagen

Hepagen 120 Capsules

item #110014
Total Quantity: 0
For cats and dogs.

Formerly Hepagen, this new and improved formula is now for dogs and cats!

Because of the toxic effects of food, water, and the environment, the liver can be a very busy organ, for humans as well as companion animals. Thorne Research Hepagen combines the beneficial liver herbs milk thistle and curcumin with antioxidants and important nutrients for phase I and II liver detoxification.

  • Thorne Research Hepagen small animal hepatic support:
  • Protects hepatic cells
  • Promotes phase I and II detoxification
  • Supports healthy glutathione levels

Pyridoxal 5'-phosphate acts as a cofactor for enzymes, catalyzes reactions with amino acids, and aids in the synthesis of nonessential amino acids. In this formula, the active form of vitamin B6, pyridoxal 5'-phosphate, is provided because healthy liver function is necessary of activation of vitamin B6. Vitamin B12 is required for proper digestion and absorption of food. It is also utilized in amino acid digestion as well as carbohydrate and fat metabolism.

Dimethylglycine (DMG) is a derivative of glycine, the simplest amino acid. It is a building block for many important substances, including methionine and choline. Methionine is an essential sulfur-containing amino acid necessary for phase II detoxification. It helps metabolize fats and is a precursor to cysteine and taurine synthesis. It can be converted to cysteine, a component of glutathione, an important endogenous antioxidant.

N-acetylcysteine (NAC) is composed of the amino acid cysteine and a sulfhydryl group, enabling it to interact with disulfide bonds. NAC serves as a nutritional precursor for the synthesis of glutathione. Reduced glutathione is an important endogenous antioxidant, essential for liver detoxification.

Silybum marianum (milk thistle) contains several potent flavolignans, including three structural isomers, silybin, silydianin, and silychristin, collectively referred to as silymarin. The antioxidant activity of silymarin appears to stabilize hepatocyte membranes, neutralize free radicals, and maintain liver glutathione levels. Curcuma longa has been used traditionally as a hepatoprotectant and cholegogue in both Chinese and Ayurvedic medicine. Its beneficial effects may be due to the fact that curcumin is a potent antioxidant and it helps maintain a normal inflammatory response.

Available in 120 Capsules.

Review Rating: 5

Country of Origin: USA

Manufacturer: Thorne Research

Shipping Weight: 0.23

L-Methionine 100 mg
N-Acetyl-L-Cysteine 100 mg
Dimethylglycine (Hydrochloride) 50 mg
Milk Thistle extract (fruit) (Silybum marianum) 50 mg
Curcumin Phytosome (Curcuma longa extract root) / Phosphatidylcholine complex) (CurcuVET®) 50 mg
Pyridoxal 5'-Phosphate (Vitamin B6) 5 mg
Methylcobalamin (Vitamin B12) 50 mcg

Other Ingredients - Hypromellose (derived from cellulose) capsule, Alaska pollock (dried skins) (Theragra chalcogramma), Leucine, Silicon Dioxide

Please Note: This product contains Milk Thistle, which may interfere with the update of P450 drugs.

Suggested Use

Dogs - 1 Capsule per 25 lbs of body weight daily


  • Ingredients in this product have not been adequately tested for use in pregnancy or lactation.
  • If animal is pregnant, lactating, or might become pregnant while taking this product, consult your veterinarian before using.
  • If animal's condition worsens or does not improve, stop product administration and consult your veterinarian
  • Do not use in high doses with anticoagulant drugs
  • May be a GI irritant

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The reviews below are presented for informational purposes only and are not intended as an endorsement of any product. The information is not intended to be a substitute for visits to your local veterinarian. Instead, these testimonials offer the reader information and opinions written by pet owners and/or veterinarians concerning animal health and products that they have used.


by PowerReviews
Thorne Research Hepagen

(based on 2 reviews)

Ratings Distribution

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  • 1 Stars



Reviewed by 2 customers

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(5 of 5 customers found this review helpful)


My senior dog is more puppy now

By Gabe's mom

from Denver, CO

About Me Long-time Pet Owner

Verified Buyer


  • Easy To Administer
  • Effective
  • Gentle
  • No Side Effects


    Best Uses

    • Daily Care
    • Older Pets
    • Treat Specific Illnesses

    Comments about Thorne Research Hepagen:

    Gabe, my 15 1/2 year old Golden/Sheltie, has had his gall bladder removed, and has a heart condition and some arthritis. I've been giving him a plethora of meds for these conditions and have been frustrated feeling that he wasn't having the quality of life I'd hoped for.
    His veterinary acupuncturist suggested that some of the meds could be causing stomach upset and should be removed.
    His veterinarian was very open and researched what especially might be a good substitute for the med we were giving him for arthritis. He came up with Hepagen-C.
    I am very happy with Gabe's progress since adding Hepagen-C to his regimen. His arthritis doesn't seem to bother him as much, his walks are longer and his spirit is much better.

    (8 of 8 customers found this review helpful)


    Fantastic product!

    By mukee

    from california

    Verified Reviewer


    • Can use for prevention
    • Can use therapeutically
    • Fantastic formulation
    • Highly reputable company


      Best Uses

      • Antioxidant
      • Elevated liver enzymes
      • Liver protection

      Comments about Thorne Research Hepagen:

      I used this product when it was found my just rescued dog had elevated liver enzymes on her initial blood test. The formulation is fantastic! And thorne already has a great reputation in the human health profession so I don't have to worry about the quality of ingredients they use.

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