Glutamine plays a key role in maintaining mucosal cell integrity and gut barrier function. Glutamine also enhances the gut's immune function, in part by increasing the production of secretory immunoglobulin a (sIgA), an antibody that promotes immunity. N-acetyl D-glucosamine (NAG) also helps maintain normal intestinal permeability. It enhances mucus production and is involved in the biosynthesis of glycosaminoglycans, the building blocks of connective tissue.

Saccharomyces boulardii is a probiotic yeast that decreases intestinal permeability. Like glutamine, this beneficial yeast exerts its protective effect on the GI tract by increasing the production of sIgA. Lactobacillus sporogenes is a safe, effective probiotic that survives in stomach acid and produces L(+) lactic acid in the intestine. Probiotics are successfully used to help maintain a healthy GI tract.

Slippery elm, a demulcent and emollient, provides soothing protection for the mucus membranes of the intestinal tract. Deglycyrrhizinated licorice (DGL) supports a healthy intestinal lining by helping to increase blood flow and maintain normal muscle relaxation.

Quercetin, an abundant dietary flavonoid, has significant positive action in the intestinal tract. Gastriplex contains Thorne Research's patented quercetin chalcone, which, because it's water-soluble, makes it a highly bioavailable form of quercetin.